CD64 is an integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is also known as Fc-gamma receptor 1 (FcγRI) or FCRI. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain, triggering cellular activation. Structurally, CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on macrophages and monocytes. CD64 is expressed on early myeloid cells and in IFNγ and G-CSF activated polymorphonuclear neutrophils (PMNs).
|Clone: 22||Isotype: IgG1 Mouse|
|The 22 antibody shows especially high affinity binding to human mononuclear phagocytes. The epitope recognized by this antibody is distinct from the IgG binding site.|
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Product Line Specifications
|Cross Reactivity||Indian Rhesus|
|Flow Product Line||IOTest|
|Item Specifications Referenced||B19718|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.