HLA-DR-PE, B8.12.2, 2 mL, ASR

IM0464U

kr3,410.00 List Price - kr3,410.00


The human major histocompatibility complex (MHC), also called human leucocyte antigens (HLA), is composed of three groups of molecules designated MHC class I, class II and class III. The MHC class II genomic region, or HLA-D region, contains the genes encoding HLA-DR, -DQ and -DP antigens. The MHC class II molecules are built by the non-covalent association of α/β heterodimers. Both heavy (α) and light (β) chains span the cell membrane. They have molecular weights of 31-33 kDa and 26-29 kDa respectively. HLA-DR molecules are found on antigen-presenting cells (APC), i.e. dendritic cells, B lymphocytes, monocytes, macrophages, Langerhans cells and thymic epithelial cells. They are also expressed on activated T cells, but not on granulocytes, platelets, or red blood cells. Resting T cells or endothelial cells that do not normally express these molecules can be induced to express them. HLA-DR is also expressed on some hematopoietic progenitor cells at different stages of differentiation.

Specifications

Target Species Human
Specificity HLA-DR
Other Names HLA Class II, HLA-DR
Fluorochrome PE
Regulatory Status ASR
Size 2 mL
Format Liquid
Flow Product Line IOTest
Clone B8.12.2
Isotype IgG2b Mouse
Clone Description HLA-DR antibodies are specific to non polymorphic determinants of human HLA class II DR molecules which are constituted of α and B polypeptides of 34 and 29 kDa respectively.
Cross Reactivity Cynomolgus Monkey, Indian Rhesus, Olive Baboon, Common Marmoset, Cotton-topped Tamarin, Squirrel Monkey

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.